Very Long Chain Fatty Acid β-Oxidation in Astrocytes: Contribution of the ABCD1-Dependent and -Independent Pathways
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چکیده
منابع مشابه
Very long chain fatty acid β-oxidation in astrocytes: contribution of the ABCD1-dependent and -independent pathways.
Very long chain fatty acid (VLCFA) metabolism in astrocytes is important for the maintenance of myelin structure in central nervous system. To analyze the contribution of the ABCD1-dependent and -independent pathways to VLCFA metabolism in astrocytes, we prepared human glioblastoma U87 cells with a silencing of ABCD1 and primary astrocytes from abcd1-deficient mice, and measured fatty acid β-ox...
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Very long chain acyl-CoA dehydrogenase is a newly characterised enzyme in mitochondrial fatty acid oxidation. A girl who presented on the second day of life with a sudden and severe illness due to deficiency of this enzyme is reported. There is evidence that some children (and perhaps all) originally diagnosed with a deficiency of long-chain acyl-CoA dehydrogenase, in fact, have a defect involv...
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Peroxisomes are organelles responsible for multiple metabolic pathways including, the biosynthesis of plasmalogens, a class of phospholipids, and the beta-oxidation of very-long-chain fatty acids (VLCFA). Lack of peroxisomes or dysfunction in any of their normal functions is the cellular basis for human peroxisomal disorders. Here we used mouse models to understand and define the biochemical an...
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BACKGROUND Utilization of energy-dense lipid fuels is critical to the rapid development and growth of neonates. OBJECTIVE To increase efficiency of milk fat utilization by newborn pigs, the effect of clofibrate on in vivo and in vitro long-chain fatty acid (LCFA) oxidation was evaluated. METHODS Newborn male pigs were administered 5 mL of vehicle (2% Tween 80) with or without clofibrate (75...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2012
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b12-00411